盈彩计划网站:胡亮 研究员 博导
胡亮
研究员
Liang Hu
research fellow
胡亮,研究员 (Liang Hu, research fellow),上海市特聘教授
电子邮箱(Email):huliang313394234@aliyun.com; 082101023@fudan.edu.cn; fcchul@zzu.edu.cn
办公室电话(TEL):(021) 5132-2266
通讯地址(contact address):浦东新区蔡伦路1200号创新科技楼4楼B407
(B407, 4/F, Innovation and Technology Building, 1200 Cailun Rd, Pudong, Shanghai)
学习和研究经历
2021.07-至今, 研究员,盈彩计划网站,中西医结合研究院
2017.11-2021.6,副研究员,郑州大学第一附属医院,心血管内科
2011.09-2017.10,助理研究员,中科院上海药物研究所,心血管药理
2013.09-2017.06,博士研究生,复旦大学,生物化学与分子生物学
2008.09-2011.06,硕士研究生,复旦大学,生物化学与分子生物学
研究领域(Research area)
血小板异常活化和心肌梗死发病机制
Mechanisms of platelet hyperactivation in myocardial infarction
传统中药抗血小板在心血管疾病中的治疗机制
Antiplatelet therapy of traditional chinese medicine in cardiovascular diseases
抗血小板药物筛选和药效学研究
Antiplatelet agent evaluation and Pharmacological study
研究成果及获奖(Achievements and Awards)
专利 (patent)
一种Galectin-3抑制剂的用途及药物组合物(an novel antiplatelet agent targeting Galectin-3)
专利申请号:202111666381.3
代表血小板反应性的生物标记物在制备心血管药物中的应用(a biomarker predicting cardiovascular diseases)
专利申请号:202111672184.2
一种双功能抗小板聚集药物及其用途 (an novel antiplatelet agent targeting P2Y12 and PDE1)
专利号(patent No.)201110034492.2
预测II型糖尿病患者心血管疾病并发症风险的生物标记物 (a biomarker predicting cardiovascular diseases in type II diabetes)
申请号 (application No.) 201510975407.5
基金支持及参与(Grant Funding)
乙酸调控Olfr78抑制心肌梗死血小板活化的机制研究 (批准编号:82270353);国家自然科学面上基金;起止日期 :2023年1月 - 2026年12月;主持人
半乳糖凝集素3高表达激活Dectin-1在急性心肌梗死血小板活化中的作用及机制研究 (批准编号:81970305);国家自然科学面上基金;起止日期 :2020年1月 - 2023年12月;主持人
瞬时电位受体TRPM8在血小板中的表达和功能(立项编号:81803522);国家自然科学青年基金;起止日期 :2019年1月 - 2021年12月;主持人
Grant Funding
2022 National Natural Science Foundation of China (general program)
2019 National Natural Science Foundation of China (general program)
2018 National Natural Science Foundation of China for Young Scientist
论文发表(Publication)
Chen Y*, Hong J*, Zhong H, Zhao Y, Li J, Shen W, Luo X, Shi H, Hu L#, Liu J#, Gao W#. IL-37 Attenuates Platelet Activation and Thrombosis Through IL-1R8 Pathway. Circ Res. 2023 Mar 31. doi: 10.1161/CIRCRESAHA.122.321787. Epub ahead of print. PMID: 36999436. (IF:23.2)
Fang L, Yu S, Tian X, Fu W, Su L, Chen Z, Yan C, He J, Hong J, Lian W, Liu G, Zhang Y, Zhou J, Hu L#. Severe fever with thrombocytopenia syndrome virus replicates in platelets and enhances platelet activation. J Thromb Haemost. 2023 Feb 13:S1538-7836(23)00145-9. doi: 10.1016/j.jtha.2023.02.006. Epub ahead of print. PMID: 36792011. (IF:16.0)
Chen Y*, Fu W*, Zheng Y, Yang J, Liu Y, Qi Z, Wu M, Fan Z, Yin K, Chen Y, Gao W, Ding Z, Dong J, Li Q#, Zhang S#, Hu L#. Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study. Eur Heart J. 2022 Feb 15:ehac034. doi: 10.1093/eurheartj/ehac034. Epub ahead of print. PMID: 35165707. (IF:35.9)
Zhang S*#, Liu Y*, Wang X*, Yang L*, Li H, Wang Y, Liu M, Zhao X, Xie Y, Yang Y, Zhang S, Fan Z, Dong J, Yuan Z, Ding Z, Zhang Y#, Hu L#. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. J Hematol Oncol. 2020 Sep 4;13(1):120. doi: 10.1186/s13045-020-00954-7. PMID: 32887634; PMCID: PMC7471641. (IF:23.1,高被引,ESI引用前1%)
Zhou Y*, Hu L*, Tang W*, Li D, Ma L, Liu H, Zhang S, Zhang X, Dong L, Shen X, Chen S, Xue R, Zhang S. Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism. J Hematol Oncol. 2021 Jan 7;14(1):9. doi: 10.1186/s13045-020-01028-4. PMID: 33413510; PMCID: PMC7791875. (IF:23.0)
Qi Z, Hu L, Zhang J, Yang W, Liu X, Jia D, Yao Z, Chang L, Pan G, Zhong H, Luo X, Yao K, Sun A, Qian J, Ding Z and Ge J. PCSK9 Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36. Circulation. 2020. (IF:39.9)
Chen Y*, Zhang H*, Hu L*, Shi H, Liu X, Jia J, Sun S, Ou Y, Luo X, Zhou G, Shen W#. Pravastatin attenuates atherosclerosis after myocardial infarction by inhibiting inflammatory Ly6C high monocytosis in apolipoprotein E knockout mice, J Int Med Res. 2020 (IF: 1.3)
陈羽斐,胡亮,张红旗,贾剑国,施海明,罗心平,周国民,范维琥,沈伟;麝香保心丸对ApoE-/-小鼠心肌梗死后动脉粥样硬化进程和循环单核细胞亚群的影响,中国中西医结合杂志;2020
Hu L, Chang L, Zhang Y, Zhai L, Zhang S, Qi Z, Yan H, Yan Y, Luo X, Zhang S, Wang Y, Kunapuli SP, Ye H, Ding Z#. Platelets express activated p2y12 receptor in patients with diabetes. Circulation. 2017 (IF: 39.9)
Zhang S, Zhang SH, Hu L, Zhai L, Xue R, Ye J, Chen L, Mruk J, Cheng G, Kunapuli SP, Ding Z#. Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis. Circulation 2015; 131(13): 1160 - 1170 (Featured work with an editorial;IF: 39.9)
Hu L, Fan Z, Du H, Ni R, Zhang S, Yin K, Ye J, Zhang Y, Wei X, Zhang X, Gross PL, Kunapuli SP, Ding Z#. BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase. Thromb Haemost 2011; 106(6): 1204 - 1214 (IF: 6.7)